Sources of bias in randomized trials and non-randomized studies of interventions: a causal inference perspective
Presented by: Jonathan Sterne, Professor of Medical Statistics and Epidemiology at the University of Bristol, and international authority in methods for evidence evaluation and synthesis.
Overview
The assessment of risk of bias in randomized trials (RCTs) and non-randomized studies of interventions (NRSI) has evolved substantially in recent years. These changes are reflected in newly available tools (ROB 2.0 for randomized trials and ROBINS-I for NRSI; see www.riskofbias.info). These new tools are based on key concepts in modern causal inference. In this course Jonathan will:
• Introduce the key features of the RoB 2.0 and ROBINS-I tools (domain-based bias assessments, use of signalling questions and algorithms to guide risk of bias judgements), and derivation of the overall risk of bias in a specified result).
• Describe the domains of bias appropriate to assessment of RCTs and NRSI.
• Describe how modern epidemiological understanding of confounding (including time-varying confounding), selection bias and misclassification bias informs the new tools.
• Explain the importance of specification of whether the effect of interest is that of assignment to intervention (the “intention to treat” effect) or that of starting and adhering to intervention (the “per protocol” effect).
Participants will use one of the new tools to assess risk of bias in either a RCT or an NRSI.
Who should attend?
This workshop is designed for clinical researchers, epidemiologists and biostatisticians who have at least some background in elementary biostatistics and basic epidemiological concepts.
Venue Details
Murdoch Children's Research Institute
Royal Children's Hospital
Walford/Cox Room (Rooms WL5.2.01 & WL5.2.03)
Level 5
50 Flemington Rd, Parkville Vic 3052.
Please note: Report to MCRI reception on Ground floor and wait for staff member escort to Level 5. Security pass is required to access lifts.
(See map attached)
COURSE FEES AND REGISTRATION
Click here to see workshop fees.
Registration now open via Trybooking.
Please note the following:
- Early bird rate until 6/3/18.
- Students must be full time. ID number is required to register.
- ViCBiostat post docs and PhD students - please refer to email from Marian regarding registration process.
- MCRI staff may request a cost centre transfer but must complete online registration process for administration purposes. Please contact Marian Chandler for details regarding the process prior to registering.
- All prices inclusive of GST.
- Registration fee includes catering.
- Course runs from 9.00am-5.00pm
- A small booking fee applies in addition to prices stated.
- Cancellation policy: refund of registration fee less 25% if cancellation within 1 week of course.
Contact Marian Chandler for any questions regarding registration.
| Attachment | Size |
|---|---|
 Level_5.pdf | 156.52 KB |
| ViCBiostat_workshopflyer_Sterne.pdf | 205.22 KB |
