Past Seminars

Seminar

Some challenges in evaluating prostate screening: subjective adjudication of outcomes, and over-diagnosis

Prof. Stephen Walter
Thursday, 13 April 2017
Time: 
12 noon - 1.00pm
This seminar is presented in conjunction with the School of Mathematics and Statistics, University of Melbourne.
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Seminar

Meta-analyses pooling results from different clinical trial designs

Dr Francois Curtin
Monday, 10 April 2017
Time: 
2.00pm-3.00pm
In the development of drugs or therapeutic interventions, the use of trials with different designs is frequent. In particular parallel group and cross-over trials are often used.
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Seminar

Statistical challenges in conducting epidemiological outcome studies with real world data

Prof. Sanjoy Paul
Thursday, 23 March 2017
Time: 
9.30am-10.30am
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Seminar

Expected residual life time and years of life lost

Mr Bendix Carstensen
Thursday, 23 February 2017
Time: 
9.30am-10.30am

In demography the actuarial estimator of the survival function has been used for centuries, typically with one year time intervals. This estimator was also the default in medical science and...

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Seminar

Improving Precision by Adjusting for Prognostic Baseline Variables in Randomized Trials, without Regression Model Assumptions

Assoc. Prof. Michael Rosenblum
Thursday, 12 January 2017
Time: 
9.30am-10.30am
In randomized clinical trials with baseline variables that are prognostic for the primary outcome, there is potential to improve precision and reduce sample size by appropriately adjusting for these variables.
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Seminar

Gerontologic Biostatistics: Modeling Longitudinal Ordinal Data in Aging

Prof. Heather Allore
Thursday, 24 November 2016
Time: 
9.30am-10.30am
In this talk Professor Allore will present the evolution of longitudinal modeling in the field of aging using ordinal data of functional disability.
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Seminar

Harnessing Crowd-Sourcing to Select Genes based on Effect Size Using Visual Inference Methods

Prof. Di Cook
Thursday, 27 October 2016
Time: 
9.30am-10.30am
The volume of high-throughput data makes it a daunting prospect to plot, but relying primarily on false discovery rate adjusted p-values is not enough. Making plots of the data is essential to diagnose the models and understand the results.
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Seminar

A cross-sectional study comparing the Whooley questions and Edinburgh postnatal depression scale against a diagnostic assessment in identifying depression in pregnancy

Dr Elizabeth Ryan
Thursday, 29 September 2016
Time: 
9.30am-10.30am

Antenatal mental disorders are often unrecognized, despite frequent contact with healthcare professionals throughout pregnancy. The UK National Institute for Clinical Excellence recommends...

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Seminar

A two-component regression model for the number of births

Prof. Gillian Heller
Thursday, 22 September 2016
Time: 
9.30am-10.30am
The number of births (parity) clearly bears a relationship to a woman’s age.
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Seminar

Epidemiological modelling in the public eye

Assoc. Prof. Manoj Gambhir
Thursday, 18 August 2016
Time: 
9.30am-10.30am
Modelling epidemics has become a commonplace activity over the past 40 years, since the publication of Professors Anderson and May's first pathbreaking papers.
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Seminar

Marginal structural models: powerful tools to estimate the causal effect of time varying exposures and the optimal dynamic regime. SEMINAR CANCELLED

Assoc. Prof. Liliana Orellana
Thursday, 28 July 2016
Time: 
9.30am-10.30am
In the first part of this talk I will introduce one of the methods to estimate the causal effect of time-varying exposures: inverse probability of treatment weighting (IPTW) of marginal structural models (MSMs).
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Seminar

Heritability, OPERA and ICE FALCON: thoughts on causation, and causes of variation in (some aspect of a) disease

Prof. John Hopper
Thursday, 26 May 2016
Time: 
9.30am - 10.30am
Heritability, as a measure of (relative) variation in genetic causes, has been well-defined for a continuous trait for nearly a century, with wise caveats from its inventor, R.A. Fisher.
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Seminar

Type-II generalised family-wise error rate formulas with application to sample size determination

Dr Benoit Liquet
Thursday, 25 February 2016
Time: 
9.30am - 10.30am
Multiple endpoints are increasingly used in clinical trials. The significance of some of these clinical trials is established if at least r null hypotheses are rejected among m that are simultaneously tested.
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Seminar

Causal modelling in randomised trials: applications and extensions of finite mixture models

Dr Richard Emsley
Thursday, 26 November 2015
Time: 
9.30am - 10.30am
Understanding treatment effect heterogeneity is an important aspect of randomised trials, and process variables describing the intervention content are crucial components of this. Frequently these variables can only be measured in intervention groups.
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Seminar

On parameter orthogonality and proper modelling of dispersion in Poisson-inverse Gaussian regression

Assoc. Prof. Stephane Heritier
Thursday, 24 September 2015
Time: 
9.30am - 10.30am
In clinical trials one traditionally models the effect of treatment on the mean response. The underlying assumption is that treatment affects the response distribution through a mean location shift on a suitable scale, with other aspects of the distribution (shape/dispersion/variance) remaining the same.
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Seminar

Why there's no such thing as an ordinal test

Prof. Thomas Lumley
Thursday, 3 September 2015
Time: 
9.30am - 10.30am
A lot of health data is ordinal: even if the measurement process is interval or ratio level, a 10mmHg blood pressure difference doesn't mean the same thing at different starting points.
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Seminar

Generalisations of the Receiver Operating Characteristic (ROC) Curve

Dr Pablo Martinez-Camblor
Thursday, 23 July 2015
Time: 
9.30am - 10.30am

The ROC curve is a popular graphical method used to study the diagnostic capacity of biomarkers. In its simplest form it plots true-positive rates against false-positive rates. Both practical and...

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Seminar

The People of the British Isles: A statistical analysis of the genetics of the UK

Dr Stephen Leslie
Thursday, 25 June 2015
Time: 
9.30am - 10.30am

Stephen will present findings from the People of the British Isles project, recently published with Stephen as first author as a cover story in one of the world’s leading scientific journals “...

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Seminar

Developing risk prediction models using nested case-control data: methods and applications

Dr Agus Salim
Thursday, 28 May 2015
Time: 
9.30am - 10.30am

In the last 10-15 years, there has been an explosion of prediction models developed to predict risk of various diseases. The main objective of a risk prediction model is to predict the absolute...

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Seminar

SMART Designs and Q-learning for Dynamic Treatment Regimens

Dr Bibhas Chakraborty
Thursday, 21 May 2015
Time: 
9.30am - 10.30am

Dynamic treatment regimens (DTRs) are sequential decision rules that specify how to adapt the type, dosage and timing of treatment according to an individual patient’s time-varying...

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Seminar

Fun ways to analyse genetic data using mixed models

Dr Doug Speed
Thursday, 30 April 2015
Time: 
9.30am - 10.30am

In 2010, Jian Yang and Peter Visscher showed how by applying mixed models to genome-wide association study data, it was possible to estimate how much of a trait's heritability is explained by all...

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Seminar

Cancer risks following diagnostic CT scans are not explained by reverse causation artefact

Prof. John Mathews
Thursday, 26 March 2015
Time: 
9.30am - 10.30am

Rates of cancer are increased following low-dose radiation from computed tomography (CT) scans used for medical diagnosis. However, when the lag period between a CT scan and diagnosis of cancer is...

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Seminar

Presenting two statistical genetics problems: Are bones found in a carpark from a specified dead king & heritability analysis in the genome era

Prof. David Balding
Thursday, 26 February 2015
Time: 
9.30am - 10.30am


Problem 1. How to evaluate the probability that bones found in a carpark are from a specified dead king:
Although the evidence for bones found under a Leicester UK...

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Seminar

Conditional versus marginal estimators of within-pair effects of exposure on outcomes in individually-matched case-control studies and twin cohorts

Assoc. Prof. Lyle Gurrin
Thursday, 27 November 2014
Time: 
9.30am - 10.30am

Data from individually-matched case-control studies, cohorts of twins and other paired designs provide a powerful resource that can be used estimate the magnitude of exposure-outcome associations...

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Seminar

The use of duration models in the estimation of causal effects: Applications from health economics

Prof. Jenny Williams
Thursday, 23 October 2014
Time: 
9.30am - 10.30am

This talk describes two approaches used in economics to identify causal effects, and illustrates their use with applications drawn from health economics. The first approach described is the...

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Seminar

Conditional autoregressive models for geographically sparse outcomes

Dr Arul Earnest
Thursday, 25 September 2014
Time: 
9.30am-10.30am

Spatial epidemiology is the description and analysis of geographically indexed health data with respect to demographic, environmental, behavioral, socioeconomic, genetic, and infectious risk...

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Seminar

Exploring the structure of whole‐genome conservation profiles using Bayesian segmentation

Dr Jonathan Keith
Thursday, 21 August 2014
Time: 
9.30am - 10.30am

Conservation is a key indicator of function in genomes, and can potentially be used to discover novel functional non‐protein‐coding RNAs and regulatory sequences. However, recent investigations...

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Seminar

Normalization

Prof. Terry Speed
Thursday, 26 June 2014
Time: 
9.30am-10.30am

Normalization is a term that has come to describe a range of adjustments done to data prior to carrying out conventional statistical analyses. Usually it is not model-based. It first...

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Seminar

Likelihood-based estimators for meta-regression analyses of standardised differences of means

Dr Luke Prendergast
Thursday, 22 May 2014
Time: 
9.30am - 10.30am

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Seminar

Drug Safety and Vioxx® Controversy

Dr KyungMann Kim
Friday, 28 March 2014
Time: 
9.30am - 10.30am

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Seminar

Trajectory Modelling by Shape

Prof. Nicholas Jewell
Thursday, 6 March 2014
Time: 
9:30am to 10:30am

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Seminar

DEPTH: A Novel Algorithm for Feature Ranking with Application to Genome-Wide Association Studies

Dr Enes Makalic
Thursday, 28 November 2013
Time: 
9:30am - 10:30am

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Seminar

Handling incomplete multilevel data using multiple imputation and meta-analysis

Dr Ian White
Thursday, 31 October 2013
Time: 
9:30am - 10:30am

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Seminar

The Dark Arts Part 2 - how to measure things we cannot see. Currrent Approaches to psychometric measurement.

Prof. Andrew MacKinnon
Thursday, 26 September 2013
Time: 
9:30am - 10:30am

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Seminar

Nonlinear mechanistic models for improving the treatment of malaria: Balancing model complexity with statistical rigour

Assoc. Prof. Julie Simpson
Thursday, 22 August 2013
Time: 
9:30am - 10:30am

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Seminar

The dark arts - how to measure things we cannot see. An introduction to psychometric measurement.

Prof. Andrew MacKinnon
Thursday, 25 July 2013
Time: 
9:30am - 10:30am

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Seminar

Design and Power Considerations for Cluster-Randomized Cross-over Designs (CRXO) with Bounded Discrete Endpoints

Assoc. Prof. John Reynolds
Thursday, 27 June 2013
Time: 
9:30am - 10:30am

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Seminar

Handling Covariate Uncertainty in Environmental Epidemiology

Prof. Louise Ryan
Thursday, 23 May 2013
Time: 
9:30am - 10:30am

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Seminar

Gene prioritisation with brain specific expression data

Dr Melanie Bahlo
Thursday, 28 March 2013
Time: 
9:30-10:30

Like many other labs around the world we are using next-generation sequencing data to identify disease causing variants, mainly for large effect size variants, such as those observed in...

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Seminar

Modelling Cumulative Effects of Time-varying Exposures/Risk Factors in Cohort Studies

Prof. Michal Abrahamowicz
Thursday, 28 February 2013
Time: 
9.30am-10.30am

Time-varying covariates are increasingly used in survival analyses of cohort studies to model the effects of prognostic factors and treatments whose values change during the follow-up. An...

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Seminar

Statistician heal thyself - have we lost the plot?

Prof. Ian Gordon
Thursday, 25 October 2012
Time: 
9.30am - 10.30am
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Seminar

Diverse Landscapes of Statistical and Operations Research Modelling in Stroke Care

Assoc. Prof. Leonid Churilov
Wednesday, 26 September 2012
Time: 
09:30 to 10:30
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Seminar

Introduction to Pharmacoepidemiology

Assoc. Prof. Alan Brookhart
Saturday, 8 September 2012
Time: 
09:00 to 16:00
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Seminar

Is the healthcare provider an instrumental variable or a confounder?

Assoc. Prof. Alan Brookhart
Wednesday, 5 September 2012
Time: 
09:30 to 10:30
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Seminar

Statistical aspects of pharmaceutical subsidy

Wednesday, 25 July 2012
Time: 
09:30 to 10:30
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Seminar

Missing data and risk prediction models

Prof. Rory Wolfe
Wednesday, 27 June 2012
Time: 
09:30 to 10:30
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Seminar

Individualized Prediction in Prostate Cancer Using Joint Longitudinal and Survival Models

Prof. Jeremy Taylor
Thursday, 23 February 2012
Time: 
9.30am
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