Meta-analyses pooling results from different clinical trial designs

Monday, 10 April 2017
Alfred Centre, Seminar Room 1, 5th floor
99 Commercial Rd
Prahran 3004

In the development of drugs or therapeutic interventions, the use of trials with different designs is frequent. In particular parallel group and cross-over trials are often used. When there is a need to pool the results of such studies into a meta-analysis, combining results from these different trials is not straightforward. We present first simple methods based on weighted average approaches to combine metrics from parallel and cross over trials. Regression methods based on generalized estimating equations as well as multilevel and Bayesian methods introducing random effects allow to combine the trial designs with the possibility to adjust for trial design specific parameters such as carry-over effect. Comparisons of the methods based on examples are presented.  Although statistical methods are available to pool results, the main limitation of the pooling exercise is the availability of the data, in particular those of cross-over trials, in order to implement the models successfully.

Dr Francois Curtin

Dr Francois Curtin

Geneuro, University of Geneva

Francois graduated in medicine from the Geneva University Medical School and from the London School of Hygiene in medical statistics (with Stuart Pocock). After several years in academic clinical research, he joined Swissmedic, the Swiss Medicine Agency in Bern and was responsible for the registration of neuro-psychiatric drugs. Then, he joined Serono SA and worked in different management positions at Serono SA and Merck Serono SA in clinical development and business development, with a particular focus on neurology and monoclonal antibodies. Since 2009, Francois is in the management of a small Swiss biotech, GeNeuro SA. He is an Academic fellow at the Geneva School of Economics and Management teaching biostatistics and is co-director of the Master of Drug discovery and development at the University of Geneva.