Gerontologic Biostatistics: Modeling Longitudinal Ordinal Data in Aging

Thursday, 24 November 2016
AMREP Education Centre, Alfred Hospital, Ground Floor, Classroom 2
Commercial Rd
Prahran 3004

In this talk Professor Allore will present the evolution of longitudinal modeling in the field of aging using ordinal data of functional disability.  The presentation will demonstrate the progression from time to event models to multistate models and recurrent events, latent trajectory and growth mixture models.  In addition, Bayesian joint longitudinal modeling with person-specific shared random intercepts will illuminate how survival estimates vary across modelling approaches.

Professor Heather Allore

Prof. Heather Allore

Director, Yale Program on Aging Biostatistics Core
Yale School of Medicine

Professor Allore's research is focused on issues related to the design and analysis of studies of multi-component interventions and the design and analysis of observational studies of multifactorial geriatric health conditions. Other areas of her applied research include developing strategies for handling missing data that frequently occurs in studies of older persons, applying extended Cox models for state transitions in geriatrics, such as frailty and disability that consist of multiple discrete states in which both onset and recovery are possible, and determining the mechanisms of action of an effective multi-component intervention. She has collaborated on several projects in immunology and is introducing new analytic methods to account for correlations among elements of the innate immune system. She developed a subdiscipline of biostatistics within the American Statistical Association that focuses on training and methodological development in Aging Research called "Gerontologic Biostatistics." This discipline trains biostatisticians for conducting collaborative clinical research with geriatricians and gerontologists in elderly populations and provide the basis for the development new statistical methodology. She served on the NIH Aging Systems and Geriatrics study section, VA Human Rights Committee, and CDC Special Emphasis study section. She has served as a reviewer and editorial board member for a variety of medical journals.

PDF icon Allore slides.pdf2.49 MB